Our client is working to identify nutritional based supplements to improve health. Our client has a drug candidate showing promise in improving cardiovascular health and endurance based on in vivo animal studies. However, the specific mechanism of action was not well understood.
We designed a study and protein expression analysis was done using reverse-phase protein lysate microarray (RPPA) from an academic core facility. Our team was able to identify patterns of protein activity and infer mechanism of action. This work makes possible the development of a screening platform to identify future compounds with a similar profile.
